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- Title
Sorafenib and sunitinib: A dermatologist's perspective.
- Authors
Pragasam, Vijendran; Verma, Rajesh; Vasudevan, Biju
- Abstract
Sorafenib and sunitinib are inhibitors of tumor angiogenesis have recently generated curiosity regarding its role in cutaneous toxicities, which has severely affected the daily activities resulting in interruption or dose modification of therapy in renal cell carcinoma and hepatocellular carcinomas. We discuss the pathophysiology, adverse cutaneous effects and their grading, potential high risk factors, role of gene polymorphism, critical period of hand-foot skin reaction development and their management.
- Subjects
PROTEIN-tyrosine kinases; PROTEIN kinases; SKIN diseases; FIBROSARCOMA; SARCOMA; GENETIC polymorphism research; THERAPEUTICS
- Publication
Indian Dermatology Online Journal, 2014, Vol 5, Issue 1, p1
- ISSN
2229-5178
- Publication type
Article
- DOI
10.4103/2229-5178.126017