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- Title
Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease.
- Authors
Huang, Ping; Li, Yibin; Nasser, M. I.; Guo, Huiming; Huang, Huanlei; Zhao, Mingyi; Zhu, Ping
- Abstract
Recent studies have demonstrated that stem cells are equipped with the potential to differentiate into various types of cells, including cardiomyocytes. Meanwhile, stem cells are highly promising in curing cardiovascular diseases. However, owing to the ethical challenges posed in stem cell acquisition and the complexity and invasive nature of the method, large-scale expansions and clinical applications in the laboratory have been limited. The current generation of cardiomyocytes is available from diverse sources; urine is one of the promising sources among them. Although advanced research was established in the generation of human urine cells as cardiomyocytes, the reprogramming of urine cells to cardiomyocytes remains unclear. In this context, it is necessary to develop a minimally invasive method to create induced pluripotent stem cells (iPSCs). This review focuses on the latest advances in research on urine-derived iPSCs and their application mechanisms in cardiovascular diseases.
- Subjects
CARDIOVASCULAR diseases; CELL differentiation; CYTOLOGY; HEART cells; MYOCARDIUM; STEM cells
- Publication
Cardiology Research & Practice, 2020, p1
- ISSN
2090-8016
- Publication type
Article
- DOI
10.1155/2020/3563519