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- Title
The Effect of Bifidobacterium animalis subsp. lactis MN-Gup on Glucose Metabolism, Gut Microbiota, and Their Metabolites in Type 2 Diabetic Mice.
- Authors
Zhang, Chao; Fang, Bing; Zhang, Nana; Zhang, Qi; Niu, Tianjiao; Zhao, Liang; Sun, Erna; Wang, Jian; Xiao, Ran; He, Jingjing; Li, Shusen; Chen, Juan; Guo, Jie; Xiong, Wei; Wang, Ran
- Abstract
Probiotics have garnered increasing attention as a potential therapeutic approach for type 2 diabetes mellitus (T2DM). Previous studies have confirmed that Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) could stimulate the secretion of glucagon-like peptide-1 (GLP-1) in NCI-H716 cells, but whether MN-Gup has a hypoglycemic effect on T2DM in vivo remains unclear. In this study, a T2DM mouse model was constructed, with a high-fat diet and streptozotocin in mice, to investigate the effect of MN-Gup on diabetes. Then, different doses of MN-Gup (2 × 109 CFU/kg, 1 × 1010 CFU/kg) were gavaged for 6 weeks to investigate the effect of MN-Gup on glucose metabolism and its potential mechanisms. The results showed that a high-dose of MN-Gup significantly reduced the fasting blood glucose (FBG) levels and homeostasis model assessment-insulin resistance (HOMA-IR) of T2DM mice compared to the other groups. In addition, there were significant increases in the short-chain fatty acids (SCFAs), especially acetate, and GLP-1 levels in the MN-Gup group. MN-Gup increased the relative abundance of Bifidobacterium and decreased the number of Escherichia-Shigella and Staphylococcus. Moreover, the correlation analysis revealed that Bifidobacterium demonstrated a significant positive correlation with GLP-1 and a negative correlation with the incremental AUC. In summary, this study demonstrates that Bifidobacterium animalis subsp. lactis MN-Gup has significant hypoglycemic effects in T2DM mice and can modulate the gut microbiota, promoting the secretion of SCFAs and GLP-1.
- Subjects
GLUCOSE metabolism; BIFIDOBACTERIUM; RESEARCH funding; HOMEOSTASIS; SHORT-chain fatty acids; GUT microbiome; GLUCAGON-like peptide 1; MICE; BLOOD sugar; INSULIN resistance; TYPE 2 diabetes; ANIMAL experimentation; AMINOGLYCOSIDES; COMPARATIVE studies; OBESITY; FASTING
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1691
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111691