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- Title
Short-Communication: Short-Term Treatment with Taurine Prevents the Development of Cardiac Hypertrophy and Early Death in Hereditary Cardiomyopathy of the Hamster and Is Sex-Dependent.
- Authors
Bkaily, Ghassan; Simon, Yanick; Normand, Alexandre; Jazzar, Ashley; Najibeddine, Houssein; Khalil, Abdelouahed; Jacques, Danielle
- Abstract
Premature death due to heart failure is a major health problem. Taurine is a non-essential amino acid that has received much attention. However, although many studies have been carried out on the beneficial effects of taurine in cardiac pathophysiology, no studies have investigated the effect of taurine treatment on the development of hereditary cardiomyopathy (HCM) associated with hypertrophy, heart failure, and early death. This study aims to verify whether short-term treatment (20 days) with taurine in tap water prevents the development of hypertrophy and premature death in hereditary cardiomyopathy of the hamster (HCMH) of the line UM-X7.1 and if its effect is sex-dependent. Our results show that treatment for 20 days with taurine (250 mg/kg/day or 25 mg/animal/day) during the development of the hypertrophic phase (220 days old) significantly decreased (p < 0.01) the heart weight to body weight ratio in male HCMHs without affecting the female. During the 20 days (220–240 days old), there were nearly 40% premature deaths in non-treated males HCMHs and 50% in female HCMHs. Treatment for 20 days wholly and significantly prevented early death in both males and females HCMHs. Our results demonstrate that short-term treatment with taurine prevents the development of cardiac hypertrophy associated with HCM in a sex-dependent manner; however, it prevents early death in a sex-independent fashion. Our results suggest that taurine supplementation could be used to treat HCM.
- Subjects
TREATMENT of cardiomyopathies; HAMSTERS; EXPERIMENTAL design; CARDIAC hypertrophy; ANIMAL experimentation; ONE-way analysis of variance; NONCARBOXYLIC acids; CARDIAC arrest; DESCRIPTIVE statistics; ALCOHOLIC cardiomyopathy; CARDIOTONIC agents; HEART failure; ANIMALS; PHARMACODYNAMICS
- Publication
Nutrients, 2022, Vol 14, Issue 16, p3287
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14163287