We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion.
- Authors
Crivelli, Joseph J.; Mitchell, Tanecia; Knight, John; Wood, Kyle D.; Assimos, Dean G.; Holmes, Ross P.; Fargue, Sonia
- Abstract
Kidney stone disease is increasing in prevalence, and the most common stone composition is calcium oxalate. Dietary oxalate intake and endogenous production of oxalate are important in the pathophysiology of calcium oxalate stone disease. The impact of dietary oxalate intake on urinary oxalate excretion and kidney stone disease risk has been assessed through large cohort studies as well as smaller studies with dietary control. Net gastrointestinal oxalate absorption influences urinary oxalate excretion. Oxalate-degrading bacteria in the gut microbiome, especially Oxalobacter formigenes, may mitigate stone risk through reducing net oxalate absorption. Ascorbic acid (vitamin C) is the main dietary precursor for endogenous production of oxalate with several other compounds playing a lesser role. Renal handling of oxalate and, potentially, renal synthesis of oxalate may contribute to stone formation. In this review, we discuss dietary oxalate and precursors of oxalate, their pertinent physiology in humans, and what is known about their role in kidney stone disease.
- Subjects
KIDNEY physiology; VITAMIN C metabolism; DIETARY supplements; KIDNEY stones; OXALIC acid; URINARY calculi; SYMPTOMS
- Publication
Nutrients, 2021, Vol 13, Issue 1, p62
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13010062