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- Title
Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease.
- Authors
Mun, Jeongeun; Kim, Shintae; Yoon, Ho-Geun; You, Yanghee; Kim, Ok-Kyung; Choi, Kyung-Chul; Lee, Yoo-Hyun; Lee, Jeongmin; Park, Jeongjin; Jun, Woojin
- Abstract
Our aim was to investigate whether hot water extract (CLW) of Curcuma longa L. could prevent non-alcoholic fatty liver disease (NAFLD). HepG2 cells were treated with free fatty acid (FFA) mixture (oleic acid: palmitic acid, 2:1) for 24 h to stimulate in vitro fatty liver. In addition, C57BL/6 mice were fed 60 kcal% high-fat (HF) diet for eight weeks to induce fatty liver in vivo. Intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) productions were increased by FFA and HF-diet, but supplementation with CLW significantly decreased these levels. CLW treatment ameliorated antioxidant activities that were suppressed by exposure to the FFA and HF-diet. Cluster of differentiation 36 (CD36) and fatty acid transport proteins (FATP2 and FATP5) were increased in HF-diet groups, while CLW suppressed their expression levels. Moreover, sterol regulatory element-binding protein-1c (SREBP-1c), acetyl-coenzyme A carboxylase (ACC), and fatty acid synthase (FAS) expression levels were down-regulated in the CLW groups compared to HF-diet groups. On the other hand, 5′ adenosine monophosphate-activated protein kinase (AMPK), Peroxisome proliferator-activated receptor alpha (PPAR-α), and carnitine palmitoyltransferase 1 (CPT-1) expressions were up-regulated in the CLW groups. HF-diet fed mice showed high hepatic triglycerides (TG) content compared to the normal diet mice. However, the administration of CLW restored the hepatic TG level, indicating an inhibitory effect against lipid accumulation by CLW. These results suggest that CLW could be a potentially useful agent for the prevention of NAFLD through modulating fatty acid uptake.
- Subjects
FATTY liver prevention; REACTIVE oxygen species; ANIMAL experimentation; ANTIOXIDANTS; CARRIER proteins; COENZYMES; DIETARY supplements; FATTY acids; MICE; TURMERIC; MALONDIALDEHYDE; PLANT extracts; IN vitro studies; IN vivo studies
- Publication
Nutrients, 2019, Vol 11, Issue 10, p2536
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11102536