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- Title
Erythrocyte Saturated Fatty Acids and Incident Type 2 Diabetes in Chinese Men and Women: A Prospective Cohort Study.
- Authors
Lin, Jie-sheng; Dong, Hong-li; Chen, Geng-dong; Chen, Zhan-yong; Dong, Xiao-wei; Zheng, Ju-sheng; Chen, Yu-ming
- Abstract
The association between circulating saturated fatty acids (SFAs) and incident type 2 diabetes (T2D) is reported in Western populations with inconsistent results, while evidence from Asian populations is scarce. We aimed to examine the associations between erythrocyte SFAs and incident T2D in a Chinese population. Between 2008 and 2013, a total of 2683 participants, aged 40–75 years, free of diabetes were included in the present analyses. Incident T2D cases were ascertained during follow-up visits. Gas chromatography was used to measure erythrocyte fatty acids at baseline. The Cox proportional hazards model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). During 13,508 person years of follow-up, 216 T2D cases were identified. Compared with the first quartile, multivariable-adjusted HRs (95% CIs) of the fourth quartile were 1.20 (0.82–1.76; p = 0.242) for myristic acid (14-carbon tail, zero double bonds; 14:0), 0.69 (0.48–0.99; p = 0.080) for palmitic acid (16:0), 1.49 (1.02–2.19; p = 0.047) for stearic acid (18:0), 1.46 (1.00–2.12; p = 0.035) for arachidic acid (20:0), 1.48 (0.99–2.22; p = 0.061) for behenic acid (22:0), and 1.08 (0.74–1.56; p = 0.913) for lignoceric acid (24:0). Our findings indicate that individual erythrocyte SFAs are associated with T2D in different directions, with 18:0 and 20:0 SFAs positively associated with the risk, whereas no convincing inverse association for 16:0 SFAs.
- Subjects
TYPE 2 diabetes risk factors; ERYTHROCYTES; CHINESE people; CONFIDENCE intervals; FATTY acids; GAS chromatography; LONGITUDINAL method; MEN'S health; WOMEN'S health; SATURATED fatty acids; PROPORTIONAL hazards models; ODDS ratio
- Publication
Nutrients, 2018, Vol 10, Issue 10, p1393
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10101393