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- Title
Lipoprotein (a) levels in diabetes mellitus: relationship to metabolic control.
- Authors
Ramirez, Luis C.; Arauz-Pacheco, Carlos; Lackner, Carolin; Albright, George; Adams, Beverly V.; Raskin, Philip; Ramirez, L C; Arauz-Pacheco, C; Lackner, C; Albright, G; Adams, B V; Raskin, P
- Abstract
<bold>Objective: </bold>To determine the influence of diabetes control on serum lipoprotein (a) concentrations.<bold>Setting: </bold>Diabetes clinic of a large metropolitan public hospital, with primary- and secondary-care patients.<bold>Design: </bold>A cross-sectional study. Comparisons of lipoprotein (a) concentrations were made between a normal control group, a group of diabetic patients with glycated hemoglobin (HbA1c) less than 8.0%, and a group of diabetic patients with HbA1c of 8.0% or higher.<bold>Patients: </bold>Ninety-five normal controls and 93 diabetic subjects (49 with insulin-dependent diabetes mellitus and 44 with noninsulin-dependent diabetes mellitus).<bold>Results: </bold>Sixty diabetic subjects with HbA1c levels of 8.0% or higher had higher (25 mg/dL) median levels of lipoprotein (a) when compared with either 93 normal controls (8.8 mg/dL) or 33 diabetic patients with HbA1c less than 8.0% (7.5 mg/dL) (P = 0.008 and P = 0.012, respectively). A similar pattern of distribution of lipoprotein (a) levels according to degree of metabolic control was seen in patients with insulin-dependent diabetes mellitus and noninsulin-dependent diabetes mellitus. No difference in the lipoprotein (a) distribution was noted between diabetic men and women. No correlation was observed between lipoprotein (a) levels and total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels.<bold>Conclusion: </bold>Lipoprotein (a) levels are elevated in poorly controlled diabetic patients. Increased levels of lipoprotein (a) may be a contributing factor to the high risk for atherosclerosis observed in diabetic patients.
- Subjects
BLOOD lipoproteins; DIABETES; SERUM
- Publication
Annals of Internal Medicine, 1992, Vol 117, Issue 1, p42
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-117-1-42