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- Title
Predictive factors for anemia response to erythropoiesis-stimulating agents in myelofibrosis.
- Authors
Hernández‐Boluda, Juan‐Carlos; Correa, Juan‐Gonzalo; García‐Delgado, Regina; Martínez‐López, Joaquín; Alvarez‐Larrán, Alberto; Fox, María‐Laura; García‐Gutiérrez, Valentín; Pérez‐Encinas, Manuel; Ferrer‐Marín, Francisca; Mata‐Vázquez, María‐Isabel; Raya, José‐María; Estrada, Natalia; García, Silvia; Kerguelen, Ana; Durán, María‐Antonia; Albors, Manuel; Cervantes, Francisco
- Abstract
Objective Erythropoiesis-stimulating agents ( ESAs) are commonly used to treat the anemia of myelofibrosis ( MF), but information on the predictors of response is limited. Methods Results of ESA therapy were analyzed in 163 MF patients with severe anemia, most of whom had inadequate erythropoietin ( EPO) levels (<125 U/L) at treatment start. Results According to the revised criteria of the International Working Group for Myelofibrosis Treatment and Research, anemia response was achieved in 86 patients (53%). Median response duration was 19.3 months. In multivariate analysis, baseline factors associated with a higher response rate were female sex ( P=.007), leukocyte count ≥10×109/L ( P=.033), and serum ferritin <200 ng/mL ( P=.002). Patients with 2 or 3 of the above features had a significantly higher response rate than the remainder (73% vs 28%, respectively; P<.001). Over the 373 patient-years of follow-up on ESA treatment, nine patients developed thrombotic complications (six arterial, three venous), accounting for 2.41 events per 100 patient-years. Survival time from ESA start was longer in anemia responders than in non-responders ( P=.011). Conclusion Besides the already established predictive value of EPO levels, these data can help to identify which MF patients are more likely to benefit from ESA treatment.
- Subjects
ANEMIA; ERYTHROPOIESIS; MULTIVARIATE analysis; MYELOFIBROSIS; THERAPEUTICS
- Publication
European Journal of Haematology, 2017, Vol 98, Issue 4, p407
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.12846