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- Title
Downregulation of Striatal Dopamine D2 Receptors in Advanced Parkinson’s Disease Contributes to the Development of Motor Fluctuation.
- Authors
Hwang, Wen-Juh; Yao, Wei-Jen; Wey, Shiaw-Pyng; Shen, Lie-Hang; Ting, Gann
- Abstract
The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson’s disease (PD). We used [sup 123] I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57 ± 0.20 vs. 1.77 ± 0.12, p = 0.009) or chronic stable PD (1.57 ± 0.20 vs. 1.77 ± 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the ‘safety factor’ for synaptic transmission and contributed to the development of motor fluctuation.Copyright © 2002 S. Karger AG, Basel
- Subjects
DOPAMINE receptors; NEUROTRANSMITTER receptors; PARKINSON'S disease; MOTOR ability; TOMOGRAPHY
- Publication
European Neurology, 2002, Vol 47, Issue 2, p113
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000047962