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- Title
Antiseptische Wirksamkeit ausgewählter Wirkstoffe und von tissue tolerable plasma (TTP) auf C. albicans-Biofilme -- hat der Reifegrad des Biofilms einen Einfluss?
- Authors
Koban, Ina; Hübner, Nils-Olaf; Matthes, Rutger; Welk, Alexander; Kindel, Eckhard; Weltmann, Klaus-Dieter; Kramer, Axel; Kocher, Thomas
- Abstract
Background: The formation of biofilms is crucial to the pathogenesis of many dental microbial infections. Oral candidosis are common and often found under removable partial dentures. Nonthermal atmospheric plasma (tissue tolerable plasma, TTP) was tested for its antimicrobial activity against different matured Candida albicans biofilms. Methods: We assessed the efficacy of selected agents (chlorhexidine, sodium hypochlorite, fluconazol) and TTP against in vitro biofilms of C. albicans grown $2 h (young), 24 h and 48 h (mature) in microtiter plates. Results: One minute TTP-treatment was shown to have significant effects on biofilm formation during the whole measurement period of young and mature biofilms. Onlythe effects of fluconazol and TTP could reduce formation of young biofilms for a longer period. Conclusions: The maturity level of biofilms influences the antiseptic efficacy of different agents. Young biofilms are very sensitive to antimicrobial effects, but they recover from it very fast. Mature biofilms show lower but long-term effects. Single plasma treatment for 1 min reduces the formation of young as well as mature biofilms. For the future physical treatment by TTP may get an alternative to chemical antisepsis.
- Subjects
CANDIDIASIS; ANTISEPTICS; DRUG efficacy; CHLORHEXIDINE; SODIUM hypochlorite; BIOFILMS; LOW temperature plasmas; INFECTION treatment; PARTIAL dentures
- Publication
GMS Krankenhaushygiene Interdisziplinaer, 2009, Vol 4, p1
- ISSN
1863-5245
- Publication type
Article