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- Title
Growth Hormone Improves Body Composition and Motor Development in Infants with Prader-Willi Syndrome After Six Months.
- Authors
Whitman, Barbara; Carrel, Aaron; Bekx, Tracy; Weber, Colleen; Allen, David; Myers, Susan
- Abstract
Background: Infants with Prader-Willi syndrome (PWS) show abnormalities of body composition. Children with PWS treated with growth hormone (GH) demonstrate improved body composition and motor skills. Objective: To assess body composition and motor changes in infants with PWS following 6 months GH therapy. Methods: Twenty-five infants with PWS (mean age 15.5 mo) underwent dual energy X-ray absorptiometry (DEXA) assessment of body composition, and motor assessment with the Toddler Infant Motor Evaluation (TIME). Patients were then randomized to treatment (Genotropin, 1 mg/m²/day) or control, with reassessment at 6 months. Results: GH treatment significantly increased lean body mass (6.4 ± 2.4 kg to 8.9 ± 2.7 kg) and decreased body fat (27.6 ± 9.9% to 22.4 ± 10.3%). Age equivalent motor scores improved 4 months in the treated group vs 2 months in controls (p <0.01). Conclusions: Infants with PWS show significant body composition and motor development improvement following 6 months GH therapy. We are investigating whether this improvement leads to long-term reductions in obesity.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2004, Vol 17, Issue 4, p591
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2004.17.4.591