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- Title
Adult patients are more catabolic than children during acute phase after burn injury: a retrospective analysis on muscle protein kinetics.
- Authors
Tuvdendorj, Demidmaa; Chinkes, David L.; Xiao-Jun Zhang; Ferrando, Arny A.; Elijah, Itoro E.; Mlcak, Ronald P.; Finnerty, Celeste C.; Wolfe, Robert R.; Herndon, David N.
- Abstract
Purpose: This study was performed to determine if there is an age-related specificity in the response of muscle protein metabolism to severe burn injury during acute hospitalization. This is a retrospective analysis of previously published data. Methods: Nineteen adult and 58 pediatric burn-injured patients (age 43.3 ± 14.3 vs. 7.2 ± 5.3 years, adult vs. children) participated in stable isotope [ ring-H]phenylalanine (Phe) infusion studies. Femoral arterial and venous blood samples and muscle biopsy samples were collected throughout the study. Data are presented as means ± standard deviation (SD). A p value less than 0.05 was considered statistically significant. Results: Muscle net protein balance (NB) was higher in children (adult vs. children, −43 ± 61 vs. 8 ± 68 nmol Phe/min/100 ml leg volume, p < 0.05). Muscle protein fractional synthesis rate (FSR) was higher in children (adult vs. children, 0.11 ± 0.05 vs. 0.16 ± 0.10 %/h, p < 0.05). Leg muscle protein breakdown was not different between the groups (adult vs. children, 179 ± 115 vs. 184 ± 124 nmol Phe/min/100 ml leg volume, p > 0.05); synthesis rate was 134 ± 96 and 192 ± 128 nmol Phe/min/100 ml leg volume in adults and children, respectively ( p = 0.07). Age significantly correlated with muscle protein NB ( p = 0.01) and FSR ( p = 0.02); but not with breakdown ( p = 0.67) and synthesis ( p = 0.07) rates measured by using a three-pool model. Conclusion: In burn injury, the muscle protein breakdown may be affected to the same extent in adults and children, whereas synthesis may have age-related specificities, resulting in a better but still low NB in children.
- Subjects
MUSCLE proteins; METABOLISM; BURN patients; CHILDREN'S injuries; PROTEIN synthesis; PHYSIOLOGY
- Publication
Intensive Care Medicine, 2011, Vol 37, Issue 8, p1317
- ISSN
0342-4642
- Publication type
Article
- DOI
10.1007/s00134-011-2223-3