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- Title
Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles.
- Authors
Zhong, Fangrui; Dou, Xiaowei; Han, Xiaoyu; Yao, Weijun; Zhu, Qiang; Meng, Yuezhong; Lu, Yixin
- Abstract
Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3‐substituted oxindoles to activated alkenes (see scheme). Biologically relevant chiral 3,3‐disubstituted oxindoles were thus prepared in high yields and with excellent enantioselectivities from 3‐aryl‐ and 3‐alkyl‐substituted oxindoles and various activated alkenes.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 3, p943
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201208285