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- Title
Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway.
- Authors
Rodriguez-Araujo, Gerardo; Nakagami, Hironori; Hayashi, Hiroki; Mori, Masaki; Shiuchi, Tetsuya; Minokoshi, Yasuhiko; Nakaoka, Yoshikazu; Takami, Yoichi; Komuro, Issei; Morishita, Ryuichi; Kaneda, Yasufumi
- Abstract
Insulin is the main glucoregulator that promotes the uptake of glucose by tissues and the subsequent utilization of glucose as an energy source. In this paper, we describe a novel glucoregulator, the alpha-synuclein (SNCA) protein, that has previously been linked to Parkinson's disease. Treatment with recombinant SNCA promotes glucose uptake in vitro in preadipocytes and in vivo in the adipose tissues and skeletal muscles of mice through the LPAR2/Gab1/PI3K/Akt pathway; these effects occur independently of the insulin receptor. This function of SNCA represents a new mechanistic insight that creates novel avenues of research with respect to the process of glucose regulation.
- Subjects
PARKINSON'S disease treatment; ALPHA-synuclein; GLUCOSE; FAT cells; PROTEIN kinases; CELLULAR signal transduction; INSULIN receptors
- Publication
Cellular & Molecular Life Sciences, 2013, Vol 70, Issue 6, p1123
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-012-1198-8