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- Title
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength.
- Authors
Xiaodong Li; Ominsky, Michael S.; Qing-Tian Niu; Ning Sun; Daugherty, Betsy; D'Agostin, Diane; Kurahara, Carole; Yongming Gao; Jin Cao; Jianhua Gong; Asuncion, Frank; Barrero, Mauricio; Warmington, Kelly; Dwyer, Denise; Stolina, Marina; Morony, Sean; Sarosi, Ildiko; Kostenuik, Paul J.; Lacey, David L.; Simonet, W. Scott
- Abstract
The article examines how targeted deletion of the sclerostin gene in laboratory mice resulted in increased bone formation and bone strength. Sclerosteosis is a high bone mass genetic abnormality in humans caused by inactivating mutations in SOST, which in the gene encoding sclerostin. Based on this information, sclerostin has become a major negative regulator of bone mass.
- Subjects
LABORATORY mice; BONE growth; BONE density; BONES; GENETICS
- Publication
Journal of Bone & Mineral Research, 2008, Vol 23, Issue 6, p860
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/jbmr.080216