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- Title
Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation.
- Authors
YANMAZ, Volkan; DISLI, Ali; YAVUZ, Serkan; OGUTCU, Hatice; DILEK, Gulay
- Abstract
A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gramnegative bacteria and for their antifungal activities against a yeast strain. The results show that all the synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs.
- Subjects
ISOXAZOLIDINES; PYRROLIDINE synthesis; RING formation (Chemistry); SPIRO compounds synthesis; NITRONES; GRAM-positive bacteria; DRUG standards; MALEIC acid
- Publication
Gazi University Journal of Science, 2019, Vol 32, Issue 1, p78
- ISSN
1303-9709
- Publication type
Article