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- Title
Desipramine inhibits Na+/H+ exchanger in human submandibular cells.
- Authors
Choi S; Li J; Jo S; Lee SJ; Oh SB; Kim J; Lee J; Park K; Choi, S-Y; Li, J; Jo, S-H; Lee, S J; Oh, S B; Kim, J-S; Lee, J-H; Park, K
- Abstract
A common and significant side-effect of the antidepressant desipramine is xerostomia (dry mouth). We investigated the effect of desipramine on Na(+)/H(+) exchanger, which is an important modulator of salivary secretion. In dissociated human submandibular acinar cells, desipramine inhibited intracellular pH recovery in a concentration-dependent manner. Likewise, 5-(N-ethyl-N-isopropyl)amiloride (EIPA), a Na(+)/H(+) exchanger inhibitor, had the same effect as desipramine, whereas the effect of 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS), a Na(+)/HCO(3)(-) co-transporter inhibitor, was not dramatic. Although desipramine is known to inhibit catecholamine re-uptake, desipramine also inhibited pH recovery in the human submandibular gland cell line, HSG cells, which lack nerve inputs. Our results suggest that desipramine directly inhibits Na(+)/H(+) exchange in human submandibular glands without the involvement of catecholamine re-uptake, revealing the cellular mechanism of desipramine-evoked xerostomia.
- Publication
Journal of Dental Research, 2006, Vol 85, Issue 9, p839
- ISSN
0022-0345
- Publication type
journal article
- DOI
10.1177/154405910608500912