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- Title
Extracellular Signal-Related Kinase Activation During Natural Reward Learning: A Physiological Role for Phasic Nucleus Accumbens Dopamine?
- Authors
Day, Jeremy J.
- Abstract
The article highlights the role of phasic nucleus accumbens (NAc) and its dopamine in extracellular signal-related kinase (ERK) activation. It mentions that the acquisition and expression of learned associations between rewards and predictive conditioned stimuli is disrupted by the microinjection of a dopamine antagonist into the NAc. It states that coactivation of N-methyl-D-aspartate (NMDA) glutamate receptors and D1 dopamine receptors is necessary in the phosphorylation of ERK in NAc.
- Subjects
NUCLEUS accumbens; DOPAMINE; PROTEIN kinases; CONDITIONED response; METHYL aspartate; PHOSPHORYLATION
- Publication
Journal of Neuroscience, 2008, Vol 28, Issue 17, p4295
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0776-08.2008