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- Title
High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity.
- Authors
Pérez-García, Felipe; Martin-Vicente, María; Rojas-García, Rosa Lía; Castilla-García, Lucía; Muñoz-Gomez, María José; Fernández, Irene Hervás; Ventosa, Victoria González; Vidal-Alcántara, Erick Joan; Cuadros-González, Juan; Bermejo-Martin, Jesús F; Resino, Salvador; Martínez, Isidoro; Hervás Fernández, Irene; González Ventosa, Victoria
- Abstract
Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity.
- Subjects
SARS-CoV-2; VIRAL load; COVID-19
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 6, p977
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab604