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- Title
Prevalence of Human Herpesvirus-8 Salivary Shedding in HIV Increases with CD4 Count.
- Authors
Gandhi, M.; Koelle, D. M.; Ameli, N.; Bacchetti, P.; Greenspan, J. S.; Navazesh, M.; Anastos, K.; Greenblatt, R. M.
- Abstract
Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir> 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.
- Subjects
UNITED States; SALIVA microbiology; HERPESVIRUS diseases; HIV-positive women; CD4 antigen; KAPOSI'S sarcoma; ORAL mucosa diseases; INFECTIOUS disease transmission
- Publication
Journal of Dental Research, 2004, Vol 83, Issue 8, p639
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/154405910408300811