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- Title
Limited maximal flow rate of target-controlled remifentanil infusion and induced cough.
- Authors
Min, S. K.; Kim, D. H.; Cho, H. B.; Moon, B. K.; Kim, J. Y.
- Abstract
Summary This study evaluated the effect of limiting maximal infusion-pump flow rate on suppression of remifentanil-induced cough during target-controlled infusion. Two hundred and ten patients were randomly assigned to receive remifentanil at an effect-site concentration of 4.0 ng.ml−1 with maximal flow rate limited to 100 (group R100), 200 (group R200), or 1200 ml.h−1 (group R1200). The number of episodes of cough were recorded and graded as mild (1-2), moderate (3-4), or severe (5 or more). The incidence of cough was 2.9% in group R100, 5.7% in group R200 and 25.7% in group R1200. Patients in group R100 and R200 had a significantly lower incidence of cough than those in group R1200 (p < 0.05). Zero, two and five patients coughed a moderate amount in groups R100, R200 and group R1200, respectively (p < 0.05). Limiting maximal infusion rate during remifentanil TCI suppressed remifentanil-induced cough.
- Subjects
COUGH; DRUG infusion pumps; ANALGESICS; ANTITUSSIVE agents; ANESTHESIA
- Publication
Anaesthesia, 2012, Vol 67, Issue 2, p145
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2011.06961.x