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- Title
Emerging Target-Based Paradigms to Prevent and Treat Migraine.
- Authors
Silberstein, S D
- Abstract
Migraine is a primary brain disorder resulting from altered modulation of normal sensory stimuli and trigeminal nerve dysfunction. The second edition of the International Classification of Headache Disorders (ICHD-2) defines seven subtypes of migraine. Migraine treatment can be acute or preventive. New targeted therapies include 5-HT1F receptor agonists, calcitonin gene-related peptide (CGRP) antagonists, nitric oxide synthetase inhibitors, and ion channel antagonists. A recent development is the creation of antibodies to CGRP and its receptor for migraine prevention.
- Subjects
MIGRAINE; HEADACHE treatment; MIGRAINE prevention; INTERNATIONAL Classification of Headache Disorder (Book); CALCITONIN gene-related peptide; NITRIC-oxide synthases; ION channels
- Publication
Clinical Pharmacology & Therapeutics, 2013, Vol 93, Issue 1, p78
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2012.198