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- Title
Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae.
- Authors
Iuchi, Hiroyuki; Ohori, Junichiro; Kiyama, Satoshi; Imuta, Naoko; Nishi, Junichiro; Kurono, Yuichi; Yamashita, Masaru
- Abstract
Background: Recurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria. Methods: The intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of S. pyogenes was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX). Results: Both NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective. Conclusion: GRNX was the most effective agent against bacteria invading cells.
- Subjects
DETROIT (Mich.); STREPTOCOCCUS pyogenes; HAEMOPHILUS influenzae; ANTIBACTERIAL agents; BACTERIA; CLARITHROMYCIN
- Publication
BMC Microbiology, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2180
- Publication type
Article
- DOI
10.1186/s12866-021-02217-y