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- Title
Effect of interleukin-1 antagonists on the quality of life in familial Mediterranean fever patients.
- Authors
Varan, Ozkan; Kucuk, Hamit; Babaoglu, Hakan; Atas, Nuh; Salman, Reyhan Bilici; Satis, Hasan; Ozturk, Mehmet Akif; Haznedaroglu, Seminur; Goker, Berna; Tufan, Abdurrahman
- Abstract
Background: Familial Mediterranean fever (FMF) patients suffer from chronic complications of disease such as AA amyloidosis, chronic arthritis, and spondylitis. Reduced quality of life (QoL) is a feature of chronic diseases but it is also impaired in patients with FMF. Despite the regular use of colchicine at a maximal dose, about 10% of patients do not respond well or resistant to colchicine (crFMF). IL-1 inhibitors have been shown to be effective in controlling attacks in crFMF patients. Herein, we aimed to investigate QoL changes of crFMF patients with IL-1 inhibitors.Methods: All patients were prospectively monitored for the frequency, duration, severity of attacks, patient global assessments (Visual Analog Scale; VAS), and laboratory features. Either anakinra or canakinumab was used as IL-1 antagonist treatments. Demographic information, MEFV gene mutations, attack characteristics, and previous treatments were registered. Short form-36 (SF-36) quality of life scale was implemented by the interviewer for evaluating the QoL before and 3 months after the treatment.Results: A total of 44 patients were included in this study. Striking improvements were detected in frequency, duration, and VAS severity of attacks (p < 0.001). In the comparison of pre- and post-treatment, SF-36 sub-components significant improvements were observed on physical function, role limitation due to physical difficulty, role limitation due to emotional problem, energy, emotional well-being, social function, pain, general health, and health change.Conclusions: In conclusion, IL-1 antagonists prevent attacks and improve QoL of crFMF.
- Subjects
FAMILIAL Mediterranean fever; QUALITY of life; INTERLEUKIN-1; VISUAL analog scale
- Publication
Clinical Rheumatology, 2019, Vol 38, Issue 4, p1125
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-018-4384-8