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- Title
Islet antibodies and remaining beta-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden.
- Authors
Schölin A; Björklund L; Borg H; Arnqvist H; Björk E; Blohmé G; Bolinder J; Eriksson JW; Gudbjörnsdottir S; Nyström L; Östman J; Karlsson AF; Sundkvist G; Schölin, A; Björklund, L; Borg, H; Arnqvist, H; Björk, E; Blohmé, G; Bolinder, J
- Abstract
<bold>Objectives: </bold>To establish the prevalence of remaining beta-cell function 8 years after diagnosis of diabetes in young adults and relate the findings to islet antibodies at diagnosis and 8 years later.<bold>Design: </bold>Population-based cohort study.<bold>Setting: </bold>Nationwide from all Departments of Medicine and Endocrinology in Sweden.<bold>Subjects: </bold>A total of 312 young (15-34 years old) adults diagnosed with diabetes during 1987-88.<bold>Main Outcome Measure: </bold>Plasma connecting peptide (C-peptide) 8 years after diagnosis. Preserved beta-cell function was defined as measurable C-peptide levels. Three islet antibodies - cytoplasmic islet cell antibodies (ICA), glutamic acid decarboxylase antibodies and tyrosine phosphatase antibodies - were measured.<bold>Results: </bold>Amongst 269 islet antibody positives (ab+) at diagnosis, preserved beta-cell function was found in 16% (42/269) 8 years later and these patients had a higher body mass index (median 22.7 and 20.5 kg m-2, respectively; P = 0.0003), an increased frequency of one islet antibody (50 and 24%, respectively; P = 0.001), and a lower prevalence of ICA (55 and 6%, respectively; P = 0.007) at diagnosis compared with ab+ without remaining beta-cell function. Amongst the 241 patients without detectable beta-cell function at follow-up, 14 lacked islet antibodies, both at diagnosis and at follow-up.<bold>Conclusions: </bold>Sixteen per cent of patients with autoimmune type 1 diabetes had remaining beta-cell function 8 years after diagnosis whereas 5.8% with beta-cell failure lacked islet autoimmunity, both at diagnosis and at follow-up.
- Publication
Journal of Internal Medicine, 2004, Vol 255, Issue 3, p384
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2003.01273.x