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- Title
Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series.
- Authors
Fabian, Victoria A; Jones, Thomas M; Wilton, Stephen D; Dench, Joanne E; Davis, Mark R; Lim, Lynnette; Kakulas, Byron A; Fabian, V A; Jones, T M; Wilton, S D; Dench, J E; Davis, M R; Lim, L; Kakulas, B A
- Abstract
<bold>Objective: </bold>To determine the relationship between the apolipoprotein E epsilon 4 allele and autopsy-verified Alzheimer's disease (AD) in an Australian population.<bold>Design: </bold>Retrospective case-control study.<bold>Setting: </bold>Royal Perth Hospital, Perth, Western Australia (a tertiary referral hospital).<bold>Subjects: </bold>50 subjects with "definite" AD (according to the histological and clinical criteria of the Consortium to Establish a Registry for Alzheimer's Disease [CERAD]) and 30 control subjects who had died from a non-neurological disease were randomly selected from the hospital's neuropathology register.<bold>Outcome Measures: </bold>Histological grading of brain sections stained with the modified Bielschowsky stain according to the criteria of CERAD; number (burden) of neuritic plaques; apolipoprotein E genotype (APOE).<bold>Results: </bold>Frequency of the epsilon 4 allele was significantly higher in the AD group (37%) than in the control group (2%) (chi 2 = 25.8; P < 0.00001). In the AD group, 50% of subjects were heterozygous for the epsilon 4 allele and 12% were homozygous, while in the control group one subject was heterozygous for the allele and none were homozygous. No association was seen between the epsilon 4 allele and neuritic plaque burden in the hippocampus, entorhinal cortex, middle frontal gyrus or inferior parietal lobule in subjects with AD.<bold>Conclusions: </bold>Our findings confirm an association between the epsilon 4 allele and autopsy-verified AD. The epsilon 4 allele may be an important risk factor for susceptibility to AD in the general Australian population.
- Subjects
BRAIN; RESEARCH; ALZHEIMER'S disease; RESEARCH methodology; RETROSPECTIVE studies; ALLELES; CASE-control method; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; APOLIPOPROTEINS; GENOTYPES; STATISTICAL sampling
- Publication
Medical Journal of Australia, 1996, Vol 165, Issue 2, p77
- ISSN
0025-729X
- Publication type
journal article
- DOI
10.5694/j.1326-5377.1996.tb124852.x