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- Title
Relaxin Modulates Fibroblast Function, Collagen Production, and Matrix Metalloproteinase-2 Expression by Cardiac Fibroblasts.
- Authors
MOOKERJEE, ISHANEE; UNEMORI, ELAINE N.; DU, XIAO‐JUN; TREGEAR, GEOFFREY W.; SAMUEL, CHRISHAN S.
- Abstract
Cardiac fibrosis is a hallmark of heart disease and involves recruitment, proliferation, and differentiation of extracellular matrix-producing fibroblasts, leading to overproduction of collagen within the myocardium. In this study, the effects of relaxin in inhibiting these processes were investigated. We used neonatal rat atrial and ventricular fibroblasts, which respond to profibrotic stimuli (i.e., transforming growth factor-β and angiotensin II) and naturally express the relaxin receptor LGR7. Relaxin significantly inhibited TGF-β- and angiotensin II-mediated fibroblast function and collagen production over a 72-h period, while increasing MMP-2 expression and activity in the presence of both profibrotic factors (all P <.05). These studies demonstrate that relaxin may have therapeutic potential in diseased states characterized by cardiac fibrosis.
- Subjects
HEART fibrosis; FIBROBLASTS; RELAXIN; EXTRACELLULAR matrix; METALLOPROTEINASES
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1041, Issue 1, p190
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1282.028