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- Title
Oxidative Stress and Changes in α- and γ-Tocopherol Levels during Coronary Artery Bypass Grafting.
- Authors
ULUS, A T; AKSOYEK, A; OZKAN, M; KATIRCIOGLU, S F; VESSBY, B; BASU, S
- Abstract
We studied whether cardiopulmonary bypass (CPB) has any immediate impact on the initiation of antioxidative defenses in the body by measuring F2-isoprostanes and α- and γ-tocopherol, respectively. 8-iso-PGF2α levels increased significantly within 3 minutes and until the end of CPB. α-Tocopherol levels increased gradually at 20 min during CPB and continued until 6 hours after CPB. γ-Tocopherol levels followed a similar fashion at the end of CPB. 8-iso-PGF2α and tocopherol levels kept at basal level 12 and 24 hours post CPB. These findings suggest that an increased free radical-induced oxidative stress together with a gradual appearance of antioxidative defense system during and after CPB.
- Subjects
CARDIOPULMONARY bypass; VITAMIN E; OXIDATIVE stress; ARTIFICIAL blood circulation; CARDIAC surgery
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1031, Issue 1, p352
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1331.043