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- Title
Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing.
- Authors
Zeng, Lin; Ming, Chen; Li, Yan; Su, Ling-Yan; Su, Yan-Hua; Otecko, Newton O; Dalecky, Ambroise; Donnellan, Stephen; Aplin, Ken; Liu, Xiao-Hui
- Abstract
The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown ratsmigrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.
- Publication
Molecular Biology & Evolution, 2018, Vol 35, Issue 1, p149
- ISSN
0737-4038
- Publication type
Article
- DOI
10.1093/molbev/msx276