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- Title
General Catalytic Methylation of Amines with Formic Acid under Mild Reaction Conditions.
- Authors
Sorribes, Iván; Junge, Kathrin; Beller, Matthias
- Abstract
A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [ N-13C]-labelled drugs in good to excellent yields under mild conditions.
- Subjects
METHYLATION; AMINES; FORMIC acid; AROMATIC compounds; SILANE compounds
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 26, p7878
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201402124