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- Title
Comparison of the Diagnostic Performance of Synthetic Versus Acquired High b-Value (1500 s/mm<sup>2</sup> ) Diffusion-Weighted MRI in Women With Breast Cancers.
- Authors
Park, Jung Hyun; Yun, Bo La; Jang, Mijung; Ahn, Hye Shin; Kim, Sun Mi; Lee, Soo Hyun; Kang, Eunyoung; Kim, Eun‐Kyu; Park, So Yeon; Kim, Eun-Kyu
- Abstract
<bold>Background: </bold>Acquired high b-value (>1000 s/mm2 ) diffusion-weighted imaging (DWI) has its strength in lesion detection. However, it is not easily used, due to a lower signal-to-noise ratio, eddy current distortions, and prolonged acquisition times. Synthetic DWI does not have these disadvantages because it is based on indirect acquisition, calculated in a voxel-wise manner.<bold>Purpose: </bold>To compare the diagnostic performance of synthetic and acquired high b-value (1500 s/mm2 ) DWI in women with breast cancer.<bold>Study Type: </bold>Retrospective.<bold>Population: </bold>A total of 108 patients (median age 49 years [range 32-77]) with 133 breast cancers.<bold>Field Strength/sequence: </bold>3T, echo-planar imaging.<bold>Assessment: </bold>Three radiologists independently reviewed image sets of both synthetic (S-b1500) and acquired (A-b1500) high b-value DWI. Malignancy confidence of the lesion was scored using a 6-point Likert-type scale.<bold>Statistical Test: </bold>Jack-knife alternative free-response receiver-operating characteristic 1 (JAFROC1) analysis was used. Sensitivity and positive predictive value (PPV) were compared using generalized estimating equations. An independent t-test was used to compare the confidence. An intraclass correlation coefficient was calculated to compare interobserver agreement.<bold>Results: </bold>The JAFROC1 figures of merit values were 0.816 and 0.808 in S-b1500 and A-b1500, respectively, with no statistically significant difference (P = 0.637). Sensitivity was higher in synthetic than in A-b1500 for readers 2 (P = 0.015) and 3 (P = 0.037). Although sensitivity was higher in S-b1500 than in A-b1500 for reader 1, the difference was not significant (P = 0.487). The PPV of S-b1500 was not significantly different from that of A-b1500 (P = 0.397). The malignancy confidence of true-positive tumors was higher in S-b1500 than in A-b1500 (P = 0.013). Interobserver agreement was good for both sequences.<bold>Data Conclusions: </bold>The synthetic high b-value DWI may improve the diagnostic sensitivity for breast cancer detection without affecting PPV compared with acquired high b-value DWI.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:857-863.
- Publication
Journal of Magnetic Resonance Imaging, 2019, Vol 49, Issue 3, p857
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26259