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- Title
Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never-smokers.
- Authors
Kindvall, Simon S.I.; Diaz, Sandra; Svensson, Jonas; Wollmer, Per; Slusarczyk, Dariusz; Olsson, Lars E.
- Abstract
<bold>Background: </bold>As several studies have provided evidence that lung disease affects the T1 of the human lung, our purpose was to investigate the effect of age on the T1-relaxation time in the lungs of healthy never-smokers, including group difference between sexes. <bold>Materials and Methods: </bold>The Snapshot FLASH pulse sequence (inversion recovery with multiple gradient echo read-outs) was used to quantify lung T1 in 30 healthy never-smoking volunteers at 1.5 Tesla. Measurements were performed under breathhold of a tidal inspiration. Additionally, subjects underwent clinical MRI and pulmonary function tests. A linear regression model of T1 as a function of age and sex was tested. <bold>Results: </bold>The slope of lung T1 at tidal end-inspiration as a function of age was statistically different between males and females (P < 0.001). In a linear regression model of T1 as a function of age and sex, females have slope of -4.1 ms/year (95% confidence interval [CI], [-5.2, -3.0]) at P < 0.001, and males -0.064 ms/year (95% CI, [-1.2, 1.1]) at P = 0.9, with a whole model R(2) = 0.83. <bold>Conclusion: </bold>The observed dependencies of lung T1 on age and sex are here attributed to a previously reported difference in blood T1 between sexes, and a previously reported decrease of pulmonary blood volume with increasing age. This may have implications for the interpretation of lung T1 measurements in both healthy individuals and patients.
- Subjects
AGE distribution; BLOOD volume; COMPARATIVE studies; LUNGS; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; REGRESSION analysis; RESEARCH; PULMONARY function tests; SEX distribution; SMOKING; EVALUATION research; BREATH holding; HUMAN research subjects; STATISTICAL models
- Publication
Journal of Magnetic Resonance Imaging, 2016, Vol 43, Issue 5, p1250
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25085