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- Title
GC-MS Chemical Characterization and Antibacterial Effect of the Essential oil of Piper mosenii.
- Authors
de Oliveira Braz, Ana Valéria; Rodrigues, Mariana Carvalho; Maia, Philippe Alencar Araújo; Pereira, Ana Paula Dantas; de Lima Silva, Jussara; Santos, Francisco Antonio Vieira dos; da Silva, Luiz Everson; Amaral, Wanderley do; Santos, Maura Lins dos; Coutinho, Henrique Douglas Melo; Baj, Tomasz; Kowalska, Grażyna; Kowalski, Radosław; Matias, Edinardo Fagner Ferreira
- Abstract
Commercialized mouthwashes are generally expensive for the most financially vulnerable populations. Thus, several studies evaluate the antimicrobial potential of herbal products, such as essential oils, to reduce the activity of microorganisms in the mouth. The objective of this research was to carry out the chemical characterization and antibacterial activity of the essential oil of Piper mosenii (EOPm), providing data that enable the development of a low-cost mouthwash formulation aimed at vulnerable communities. The analysis of the antibacterial potential and modulator of bacterial resistance was verified by the microdilution method to determine the minimum inhibitory concentration-MIC. The chemical components were characterized by gas chromatography coupled to mass spectrometry, where 23 chemical constituents were detected, with α-pinene, being the major compound. The EOPm showed a MIC ≥ 1024 µg/mL for all bacterial strains used in the tests. When the EOPm modulating activity was evaluated together with chlorhexidine, mouthwash and antibiotics against bacterial resistance, the oil showed a significant synergistic effect, reducing the MIC of the products tested in combination, in percentages between 20.6% to 96.3%. Therefore, it is recommended to expand the tests with greater variation of EOPm concentration and the products used in this research, in addition to the evaluation of toxicity and in vivo tests, seeking the development of a possible formulation of mouthwash accessible to the vulnerable population.
- Subjects
ESSENTIAL oils; TOXICITY testing; GAS chromatography/Mass spectrometry (GC-MS); DRUG resistance in bacteria; MASS spectrometry; MOUTHWASHES; COMMUNITIES
- Publication
Molecules, 2022, Vol 27, Issue 18, p5911
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27185911