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- Title
Fabrication of Magnetic Al-Based Fe 3 O 4 @MIL-53 Metal Organic Framework for Capture of Multi-Pollutants Residue in Milk Followed by HPLC-UV.
- Authors
Liu, Xue-Li; Wang, Yong-Hui; Ren, Shu-Yue; Li, Shuang; Wang, Yu; Han, Dian-Peng; Qin, Kang; Peng, Yuan; Han, Tie; Gao, Zhi-Xian; Cui, Jian-Zhong; Zhou, Huan-Ying
- Abstract
The efficient capture of multi-pollutant residues in food is vital for food safety monitoring. In this study, in-situ-fabricated magnetic MIL-53(Al) metal organic frameworks (MOFs), with good magnetic responsiveness, were synthesized and applied for the magnetic solid-phase extraction (MSPE) of chloramphenicol, bisphenol A, estradiol, and diethylstilbestrol. Terephthalic acid (H2BDC) organic ligands were pre-coupled on the surface of amino-Fe3O4 composites (H2BDC@Fe3O4). Fe3O4@MIL-53(Al) MOF was fabricated by in-situ hydrothermal polymerization of H2BDC, Al (NO3)3, and H2BDC@Fe3O4. This approach highly increased the stability of the material. The magnetic Fe3O4@MIL-53(Al) MOF-based MSPE was combined with high-performance liquid chromatography-photo diode array detection, to establish a novel sensitive method for analyzing multi-pollutant residues in milk. This method showed good linear correlations, in the range of 0.05–5.00 μg/mL, with good reproducibility. The limit of detection was 0.004–0.108 μg/mL. The presented method was verified using a milk sample, spiked with four pollutants, which enabled high-throughput detection and the accuracies of 88.17–107.58% confirmed its applicability, in real sample analysis.
- Subjects
IRON oxides; METAL-organic frameworks; SOLID phase extraction; BISPHENOL A; MILK
- Publication
Molecules, 2022, Vol 27, Issue 7, p2088
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27072088