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- Title
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity.
- Authors
Kogan, Natalya M.; Lavi, Yarden; Topping, Louise M.; Williams, Richard. O.; McCann, Fiona E.; Yekhtin, Zhanna; Feldmann, Marc; Gallily, Ruth; Mechoulam, Raphael
- Abstract
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.
- Subjects
HIGH-fat diet; OBESITY; INFLAMMATION; DRUG development; FATTY degeneration
- Publication
Molecules, 2021, Vol 26, Issue 18, p5601
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26185601