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- Title
Secondary S100B Protein Increase Following Brain Arteriovenous Malformation Rupture is Associated with Cerebral Infarction.
- Authors
Garzelli, Lorenzo; Jacquens, Alice; Amouyal, Caroline; Premat, Kevin; Sourour, Nader; Cortese, Jonathan; Haffaf, Idriss; Mathon, Bertrand; Lenck, Stéphanie; Clarençon, Frédéric; Degos, Vincent; Shotar, Eimad; Donato, Rosario Francesco
- Abstract
Early S100B protein serum elevation is associated with poor prognosis in patients with ruptured brain arteriovenous malformations (BAVM). The purpose of this study is to determine whether a secondary elevation of S100B is associated with early complications or poor outcome in this population. This is a retrospective study of patients admitted for BAVM rupture. A secondary increase of S100B was defined as an absolute increase by 0.1 μg/L within 30 days of admission. Fisher's and unpaired t tests followed by multivariate analysis were performed to identify markers associated with this increase. Two hundred and twenty-one ruptures met inclusion criteria. Secondary S100B protein serum elevation was found in 17.1% of ruptures and was associated with secondary infarction (p < 0.001), vasospasm-related infarction (p < 0.001), intensive care (p = 0.009), and hospital length of stay (p = 0.005), but not with early rebleeding (p = 0.07) or in-hospital mortality (p = 0.99). Secondary infarction was the only independent predictor of secondary increase of S100B (OR 9.9; 95% CI (3–35); p < 0.001). Secondary elevation of S100B protein serum levels is associated with secondary infarction in ruptured brain arteriovenous malformations.
- Subjects
CEREBRAL arteriovenous malformations; CEREBRAL infarction; BLOOD proteins; LENGTH of stay in hospitals; HOSPITAL mortality
- Publication
Molecules, 2020, Vol 25, Issue 21, p5177
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25215177