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- Title
Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu "Kadsura coccinea" Stems.
- Authors
Huang, Sheng Zhuo; Duan, Lin Ping; Wang, Hao; Mei, Wen Li; Dai, Hao Fu
- Abstract
Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman's Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.
- Subjects
MASS analysis (Spectrometry); ACETYLCHOLINESTERASE; NUCLEAR magnetic resonance; DIETARY supplements
- Publication
Molecules, 2019, Vol 24, Issue 19, p3628
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24193628