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- Title
Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii.
- Authors
Dongsheng Fan; Guo-Yuan Zhu; Ting Li; Zhi-Hong Jiang; Li-Ping Bai
- Abstract
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3'-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.
- Subjects
SESQUITERPENES; PYRIDINE; ALKALOIDS; TRIPTERYGIUM wilfordii; CELL proliferation
- Publication
Molecules, 2016, Vol 21, Issue 9, p1146
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21091146