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- Title
Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core.
- Authors
Ötvös, Sándor B.; Chi-Ting Hsieh; Yang-Chang Wu; Jih-Heng Li; Fang-Rong Chang; Fülöp, Ferenc
- Abstract
Flow chemistry-based syntheses of deuterium-labeled analogs of important antidiabetic chalcones were achieved via highly controlled partial C≡C bond deuteration of the corresponding 1,3-diphenylalkynones. The benefits of a scalable continuous process in combination with on-demand electrolytic D2 gas generation were exploited to suppress undesired over-reactions and to maximize reaction rates simultaneously. The novel deuterium-containing chalcone derivatives may have interesting biological effects and improved metabolic properties as compared with the parent compounds.
- Publication
Molecules, 2016, Vol 21, Issue 3, p318
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21030318