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- Title
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity.
- Authors
Pahontu, Elena; Fala, Valeriu; Gulea, Aurelian; Poirier, Donald; Tapcov, Victor; Rosu, Tudor
- Abstract
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H2L1-H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
- Subjects
ORGANIC synthesis; THIOSEMICARBAZONES; CONDENSATION reactions; NUCLEAR magnetic resonance; MAGNETOCHEMISTRY; MOLECULAR structure of ligands; X-ray diffraction
- Publication
Molecules, 2013, Vol 18, Issue 8, p8812
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18088812