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- Title
The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides.
- Authors
Brand, Guilherme D.; Santos, Raimunda C.; Arake, Luisa Mayumi; Silva, Valdelânia G.; Veras, Leiz M. C.; Costa, Vladimir; Costa, Carlos Henrique N.; Kuckelhaus, Selma S.; Alexandre, José Guilherme; Feio, Maria J.; Leite, José Roberto S. A.
- Abstract
Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.
- Subjects
BRAZIL; PEPTIDE antibiotics; LEAF frogs; PHYLLOMEDUSA; LEISHMANIA; PEPTIDE synthesis
- Publication
Molecules, 2013, Vol 18, Issue 6, p7058
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18067058