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- Title
Antioxidant Bibenzyl Derivatives from Notholaena nivea Desv.
- Authors
Cioffi, Giuseppina; Montoro, Paola; de Ugaz, Olga Lock; Vassallo, Antonio; Severino, Lorella; Pizza, Cosimo; de Tommasi, Nunziatina
- Abstract
Four new bibenzyl derivatives were isolated, together with other known bibenzyls, by bioassay-guided fractionation of a CHCl3-MeOH extract of Notholaena nivea Desv. (Pteridaceae) aerial parts. The structures were elucidated by NMR, ESIMS and other spectral analyses. Their antioxidative effects towards superoxide, lipidic peroxidation and the 2,2′-azino-bis-3-ethilbenzothiazoline-6-sulfonic acid (ABTS) radical were assayed. Results showed that the compound 3,12-dihydroxy-5-methoxybibenzyl (6) is the most active compound in the ABTS free-radical scavenging test, while in the coupled oxidation of β-carotene and linoleic acid assay the compound 5,12-dihydroxy-3-methoxydibenzyl-6-carboxylic acid (1) exerted the highest activity after 1h. A superoxide anion enzymatic test was also carried out and the results were confirmed by an inhibition of xanthine oxidase activity assay. The putative protective role played by compounds 1 and 6 on the injurious effects of reactive oxygen metabolites on the intestinal epithelium, using a Caco-2 human cell line, was investigated. H2O2-induced alterations were prevented by preincubating the cells with compounds 1 and 6.
- Subjects
ANTIOXIDANTS; BIOLOGICAL assay; SUPEROXIDES; PEROXIDATION; SULFONIC acids; XANTHINE oxidase
- Publication
Molecules, 2011, Vol 16, Issue 3, p2527
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16032527