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- Title
Colorectal cancer: Mutations in a signalling pathway.
- Authors
Parsons, D. Williams; Tian-Li Wang; Samuels, Yardena; Bardelli, Alberto; Cummins, Jordan M.; de Long, Laura; Silliman, Natalie; Ptak, Janine; Szabo, Steve; Willson, James K. V.; Markowitz, Sanford; Kinzler, Kenneth W.; Vogelstein, Bert; Lengauer, Christoph; Velculescu, Victor E.
- Abstract
Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.
- Subjects
COLON cancer; GENETIC mutation; CELLULAR signal transduction; PROTEIN kinases; ENZYMES; CELL growth
- Publication
Nature, 2005, Vol 436, Issue 7052, p792
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/436792a