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- Title
Functional Activity of Th-17 Lymphocytes in Pulmonary Tuberculosis.
- Authors
Kononova, T.; Urazova, O.; Novitskii, V.; Churina, E.; Kolobovnikova, Yu.; Ignatov, M.; Zakharova, P.; Pechenova, O.
- Abstract
Increased content of CD4CD161IL-17A Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.
- Subjects
LYMPHOCYTES; TUBERCULOSIS research; CD4 antigen; CYTOKINES; IMMUNE response
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 156, Issue 6, p743
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2438-8