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- Title
Antiaggregant Activity of a New Benzimidazole Derivative.
- Authors
Kucheryavenko, A.; Spasov, A.; Petrov, V.; Anisimova, V.
- Abstract
Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evaluated the effect of this substance on blood coagulation potential. Antiaggregant agent acetylsalicylic acid was used as the reference drug. RU-891 produced a dose-dependent antiaggregant effect in vivo and in vitro that exceeded the effect of the reference drug. This compound did not modulate blood coagulation potential.
- Subjects
TRICYCLIC antidepressants; BENZIMIDAZOLE derivatives; BLOOD platelet aggregation; ASPIRIN; BLOOD coagulation
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 156, Issue 6, p796
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2453-9