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- Title
KIT ligand and bone morphogenetic protein signaling enhances human embryonic stem cell to germ-like cell differentiation.
- Authors
West, F. D.; Roche-Rios, M. I.; Abraham, S.; Rao, R. R.; Natrajan, M. S.; Bacanamwo, M.; Stice, S. L.
- Abstract
BACKGROUND: Signaling mechanisms involved in early human germ cell development are largely unknown and believed to be similar to mouse germ cell development; however, there may be species specific differences. KIT ligand (KITL) and Bone morphogenetic protein 4 (BMP4) are necessary in mouse germ cell development and may play an important role in human germ cell development.
- Subjects
GERM cells; BONE morphogenetic proteins; HUMAN beings; EMBRYOLOGY; MICE; RESEMBLANCE (Philosophy)
- Publication
Human Reproduction, 2010, Vol 25, Issue 1, p168
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/dep338