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- Title
The mouse as a model for human biology: a resource guide for complex trait analysis.
- Authors
Peters, Luanne L.; Robledo, Raymond F.; Bult, Carol J.; Churchill, Gary A.; Paigen, Beverly J.; Svenson, Karen L.
- Abstract
The mouse has been a powerful force in elucidating the genetic basis of human physiology and pathophysiology. From its beginnings as the model organism for cancer research and transplantation biology to the present, when dissection of the genetic basis of complex disease is at the forefront of genomics research, an enormous and remarkable mouse resource infrastructure has accumulated. This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits.
- Subjects
LABORATORY mice; GENETICS; HUMAN physiology; PATHOLOGICAL physiology; MOLECULAR genetics; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; DATABASES; GENES; RESEARCH methodology; MEDICAL cooperation; MICE; GENETIC mutation; RESEARCH; GENOMICS; EVALUATION research
- Publication
Nature Reviews Genetics, 2007, Vol 8, Issue 1, p58
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg2025