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- Title
Population-specific patterns of linkage disequilibrium in the human 5q31 region.
- Authors
Luoni, G.; Forton, J.; Jallow, M.; Akha, E. Sadighi; Sisay-Joof, F.; Pinder, M.; Hanchard, N.; Herbert, M.; Kimber, M.; Mott, R.; Hull, J.; Rockett, K.; Kwiatkowski, D.
- Abstract
Linkage disequilibrium across the human genome is generally lower in West Africans than Europeans. However in the 5q31 region, which is rich in immune genes, we find significantly more examples of apparent nonrecombination between distant marker pairs in West Africans. Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population.Genes and Immunity (2005) 6, 723–727. doi:10.1038/sj.gene.6364250; published online 28 July 2005
- Subjects
HUMAN genome; GENE mapping; LINKAGE (Genetics); WEST Africans; EUROPEANS; POPULATION genetics; GENETICS
- Publication
Genes & Immunity, 2005, Vol 6, Issue 8, p723
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364250