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- Title
A highly polymorphic CA repeat marker at the interleukin-11 locus.
- Authors
Ota, N; Nakajima, T; Takeuchi, T; Shirai, Y; Emi, M
- Abstract
The interleukin-11 (IL-11) stimulates T cell-dependent development of immunoglobulin-producing B cells and collaborates with IL-3 in supporting murine megakaryocyte colony formation. The interleukin-11 (IL-11) also stimulates osteoclast formation and inhibits osteoclast function in vitro and has been implicated in estrogen deficiency-induced bone loss. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the IL-11 gene located at 19q13.3-q13.4. High heterozygosity (0.81) makes this polymorphism a useful marker in genetic study of disorders affecting immune response and bone metabolism.
- Subjects
GENETIC polymorphisms; GENETIC markers; INTERLEUKINS
- Publication
Genes & Immunity, 1999, Vol 1, Issue 2, p159
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6363637